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CRISPR/Cas9 off-target edit

Papers on CRISPR/Cas9 off-target edit

2016 May 20. doi: 10.1038/mt.2016.107. [Epub ahead of print]

CRISPR repair reveals causative mutation in a preclinical model of retinitis pigmentosa.

http://www.ncbi.nlm.nih.gov/pubmed/27203441

2016 May 11. pii: g3.116.030601. doi: 10.1534/g3.116.030601. [Epub ahead of print]

CRISPR/Cas9 Mediated Insertion of loxP Sites in the Mouse Dock7 Gene Provides an Effective Alternative to Use of Targeted Embryonic Stem Cells.

http://www.ncbi.nlm.nih.gov/pubmed/27175020

FEBS J. 2016 May 21. doi: 10.1111/febs.13760. [Epub ahead of print]

Off-target effects of engineered nucleases.

http://www.ncbi.nlm.nih.gov/pubmed/27208701

Sci Rep. 2016 Mar 4;6:22555. doi: 10.1038/srep22555.

Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9Gene Editing.

http://www.ncbi.nlm.nih.gov/pubmed/26939770

Methods Cell Biol. 2015;129:19-36. doi: 10.1016/bs.mcb.2015.03.017. Epub 2015 May 27.

Generation of a conditional analog-sensitive kinase in human cells usingCRISPR/Cas9-mediated genome engineering.

http://www.ncbi.nlm.nih.gov/pubmed/26175431

Cell Stem Cell. 2015 Aug 6;17(2):233-44. doi: 10.1016/j.stem.2015.06.001. Epub 2015 Jul 2.

Engineering Human Stem Cell Lines with Inducible Gene Knockout usingCRISPR/Cas9.

http://www.ncbi.nlm.nih.gov/pubmed/26145478

Curr Protoc Stem Cell Biol. 2015;35:5A.8.1-22. doi: 10.1002/9780470151808.sc05a08s35. Epub 2015 Nov 4.

Crispr-mediated Gene Targeting of Human Induced Pluripotent Stem Cells.

http://www.ncbi.nlm.nih.gov/pubmed/26949444

PLoS One. 2014 Aug 28;9(8):e105779. doi: 10.1371/journal.pone.0105779. eCollection 2014.

Optimization of genome engineering approaches with the CRISPR/Cas9system.

http://www.ncbi.nlm.nih.gov/pubmed/25166277

PLoS One. 2014 Feb 11;9(2):e88146. doi: 10.1371/journal.pone.0088146. eCollection 2014.

Generation of TALEN-mediated GRdim knock-in rats by homologous recombination.

http://www.ncbi.nlm.nih.gov/pubmed/24523878

Nucleic Acids Res. 2013 Oct;41(19):e180. doi: 10.1093/nar/gkt721. Epub 2013 Aug 13.

Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells.

http://www.ncbi.nlm.nih.gov/pubmed/23945944

Plant Biotechnol J. 2016 Apr;14(4):1151-60. doi: 10.1111/pbi.12483. Epub 2015 Oct 1.

Targeted gene exchange in plant cells mediated by a zinc finger nuclease double cut.

http://www.ncbi.nlm.nih.gov/pubmed/26426390

Nucleic Acids Res. 2011 Sep 1;39(17):7868-78. doi: 10.1093/nar/gkr421. Epub 2011 Jun 7.

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase.

http://www.ncbi.nlm.nih.gov/pubmed/21653554

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